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Hypertension: Causes, Types, Risk factors & Medication

February 23, 2023

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High blood pressure, also called hypertension, is blood pressure that is higher than normal. Your blood pressure changes throughout the day based on your activities. Having blood pressure measures consistently above normal may result in a diagnosis of high blood pressure (or hypertension).

What is Hypertension

Hypertension, also known as high or raised blood pressure, is a condition in which the blood vessels have persistently raised pressure. Blood is carried from the heart to all parts of the body in the vessels. Each time the heart beats, it pumps blood into the vessels.

Blood pressure is created by the force of blood pushing against the walls of blood vessels (arteries) as it is pumped by the heart. The higher the pressure, the harder the heart has to pump.

Hypertension is a serious medical condition and can increase the risk of heart, brain, kidney and other diseases. It is a major cause of premature death worldwide, with upwards of 1 in 4 men and 1 in 5 women – over a billion people ­– having the condition. The burden of hypertension is felt disproportionately in low- and middle-income countries, where two thirds of cases are found, largely due to increased risk factors in those populations in recent decades.

Hypertension Statistics worldwide

  • An estimated 1.28 billion adults aged 30-79 years worldwide have hypertension, most (two-thirds) living in low- and middle-income countries
  • An estimated 46% of adults with hypertension are unaware that they have the condition.
  • Less than half of adults (42%) with hypertension are diagnosed and treated.
  • Approximately 1 in 5 adults (21%) with hypertension have it under control.
  • Hypertension is a major cause of premature death worldwide.
  • One of the global targets for noncommunicable diseases is to reduce the prevalence of hypertension by 33% between 2010 and 2030.

Hypertension causes

Blood pressure is given as a reading of two numbers, such as 110/70. The higher number (systolic) is the pressure when the heart beats. The diastolic, or lower number shows the pressure between the heartbeats, while the relaxed heart is refilling with blood. Normal blood pressure readings are lower than 120/80. The cause of most hypertension is unknown. Occasionally, conditions of the kidney or adrenal gland are the cause of high blood pressure.

There are several factors that may cause high blood pressure, but the exact cause is unknown. The following factors may increase one’s risk for high blood pressure:

  • Smoking
  • Overweight or obesity
  • Lack of physical activity
  • Too much salt consumption
  • Too much alcohol consumption (more than 1 to 2 drinks per day)
  • Stress
  • Older age
  • Genetics
  • Family history of high blood pressure
  • Chronic kidney disease
  • Adrenal and thyroid disorders
  • Sleep apnea

 Types of hypertension

There are two types of hypertension:

  • Primary: High blood pressure that is not related to another medical condition.
  • Secondary: Another medical condition that causes high blood pressure, usually occurring in the kidneys, arteries, heart, or endocrine system. Examples include: Sleep problems like sleep apnea.

Hypertension stages

Under the new 2017 guidelines, all blood pressure measurements over 120/80 mm Hg are considered elevated.

Now blood pressure measurements are categorized as follows:

  • Normal: systolic less than 120 mm Hg and diastolic less than 80 mm Hg
  • Elevated: systolic between 120-129 mm Hg and diastolic less than 80 mm Hg
  • Stage 1: systolic between 130-139 mm Hg or diastolic between 80-89 mm Hg
  • Stage 2: systolic at least 140 mm Hg or diastolic at least 90 mm Hg

Risk factors of hypertension

The top 10 risk factors for high blood pressure include:

1. Being overweight or obese

The more you weigh the more blood flow you need to supply oxygen and nutrients to your tissues. As the volume of blood circulated through your blood vessels increases, so does the pressure inside your arteries.

2. Too much salt (sodium) in your diet

Too much sodium in your diet can cause your body to retain fluid, and also causes the arteries in your body to constrict. Both factors increase blood pressure.

3. Too little potassium in your diet

Potassium helps balance the amount of sodium in your cells. Potassium causes the smooth muscle cells in your arteries to relax, which lowers blood pressure.

4. Not being physically active

Exercise increases blood flow through all arteries of the body, which leads to release of natural hormones and cytokines that relax blood vessels, which in turn lowers blood pressure. Lack of physical activity also increases the risk of being overweight.

5. Drinking too much alcohol

Having more than two drinks per day can cause hypertension, probably by activating your adrenergic nervous system, causing constriction of blood vessels and simultaneous increase in blood flow and heart rate.

6. Stress

High levels of stress can lead to a temporary, but dramatic, increase in blood pressure. If you try to relax by eating more, using tobacco or drinking alcohol, you may only exacerbate problems with high blood pressure. Relaxation and meditation techniques effectively lower blood pressure.

7. Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Ibuprofen (Advil, Motrin, Ibuprofen) can cause marked worsening of existing hypertension or development of new high blood pressure. It can also cause damage to the kidneys, worsening of heart failure, and even heart attack or stroke. Ibuprofen is a member of the class of drugs called NSAIDs, which includes naproxen (Aleve, Naprosyn and Anaprox), sulindac (Clinoril), diclofenac (Voltaren), piroxicam (Feldene), indomethacin (Indocin), Mobic, Lodine and celecoxib (Celebrex).

8. Cough and Cold Medications (Sudafed and other brands that contain pseudoephedrine and phenylephrine)

Cough and cold medicines frequently contain decongestants such as pseudoephedrine and phenylephrine. These medications cause your blood pressure and heart rate to rise, by constricting all your arteries, not just those in your nose.

9. Certain chronic conditions

Certain chronic conditions, including diabetes, kidney disease and sleep apnea, also may increase your risk of high blood pressure.

10. A diet low in vitamin D

It’s uncertain if having too little vitamin D in your diet can lead to high blood pressure. Researchers think that vitamin D may affect an enzyme produced by your kidneys that affects your blood pressure. More studies are necessary to determine vitamin D’s exact role in high blood pressure. However, talk to your doctor about whether you may benefit from taking a vitamin D supplement.

Hypertension medication

One or more of these blood pressure medicines are often used to treat high blood pressure:

  • Diuretics are also called water pills. They help your kidneys remove some salt (sodium) from your body. As a result, your blood vessels don’t have to hold as much fluid and your blood pressure goes down.
  • Beta-blockers make the heart beat at a slower rate and with less force.
  • Angiotensin-converting enzyme inhibitors (also called ACE inhibitors) reduce the production of angiotensin II in your body. This helps relax your blood vessels, which lowers your blood pressure.
  • Angiotensin II receptor blockers (also called ARBs) reduce the action of angiotensin II in your body. This helps relax your blood vessels, which lowers your blood pressure.
  • Calcium channel blockers relax blood vessels by reducing calcium entering cells in the wall of the blood vessels.

 

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Published February 23, 2023

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